Phaeohyphomycosis and role of internal transcribed spacer

Lokeshwari Gopal; G Balajee; KS Mouleeswaran; Anupma Jyoti Kindo; Subramanian Swaminathan; G Srividhya; Selva Seetharaman; Arun Kumar; Muthukumar Periasamy; Nigel Peter Symss

doi:10.4103/jacm.jacm_66_21

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ORIGINAL ARTICLE

Year : 2021 | Volume : 23 | Issue : 2 | Page : 51-58

Phaeohyphomycosis and role of internal transcribed spacer

Lokeshwari Gopal¹, G Balajee¹, KS Mouleeswaran², Anupma Jyoti Kindo³, Subramanian Swaminathan⁴, G Srividhya⁴, Selva Seetharaman⁵, Arun Kumar⁶, Muthukumar Periasamy⁷, Nigel Peter Symss⁸
¹ Department of Microbiology, Gleneagles Global Health City, Chennai, Tamilnadu, India
² Department of Pathology, Gleneagles Global Health City, Chennai, Tamilnadu, India
³ Department of Microbiology, SRMC and RI, Sri Ramachandra University, Chennai, Tamilnadu, India
⁴ Department of Infectious Disease, Gleneagles Global Health City, Chennai, Tamilnadu, India
⁵ Department of Plastic, Cosmetic and Aesthetic Surgery, Gleneagles Global Health City, Chennai, Tamilnadu, India
⁶ Department of Plastic, Cosmetic and Reconstructive Surgery, Gleneagles Global Health City, Chennai, Tamilnadu, India
⁷ Department of Nephrology, Cosmetic and Reconstructive Surgery, Gleneagles Global Health City, Chennai, Tamilnadu, India
⁸ Department of Neurosurgery, Gleneagles Global Health City, Chennai, Tamilnadu, India

Correspondence Address:
Dr. Lokeshwari Gopal
Department of Microbiology, Gleneagles Global Health City, No. 439, Cheran Nagar, Perumbakkam, Chennai - 600 100, Tamil Nadu
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/jacm.jacm_66_21

Phaeohyphymocosis is caused by a heterogeneous group of black-pigmented fungi. Clinical manifestations range from small localised subcutaneous lesion to life-threatening invasive and disseminated infection. With increase in immunocompromised patients due to various conditions, phaeoid fungus has gained its role as a pathogen in human diseases. There is no pathognomonic clinical or radiological feature to diagnose phaeohyphomycosis. Thus, the role of diagnostics in histopathology and microbiology is important in identification and diagnosis of this clinical condition. Specimens received for fungal identification were cultured on Sabouraud's Dextrose Agar with 10 mg/L Chloramphenicol (SCA) and identified by conventional methods. Few phaeoid fungi, which did not sporulate even after prolonged incubation under appropriate conditions in routine culture media, were identified by Internal Transcribed Spacer sequencing. Here, we present case series of five patients presented to our hospital with brain abscess, post traumatic wound, two post renal transplant recipients with skin and soft tissue infections, diabetes-associated soft tissue swelling and diagnosed with phaeohyphomycosis from 2017 to 2019.

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